Iconic shooter game Doom is known for its ability to operate on virtually any platform, ranging from ATM devices to pregnancy test kits, and even extending to blockchain technology systems. Despite the intense dedication of enthusiasts committed to adapting Doom for use on a variety of platforms, this particular instance is exceptionally unexpected. According to recent research by scholars at the Massachusetts Institute of Technology (MIT), it’s theoretically possible to operate Doom using E. coli bacteria. According to Rock Paper Shotgun’s initial report, the ongoing trial adds to the evidence that the iconic game is capable of operating on just about any device, albeit the gameplay might not be especially enjoyable. Lauren “Ren” Ramlan, a biotech graduate student at MIT, remarked that a display and determination are all that’s required to play ‘Doom.’ In her study, Ramlan suggested the idea of utilizing E. coli bacteria housed in a well plate of 32×48 to link with a display controller. Within the dish, the cavities act as individual picture elements. A display controller converts Doom’s graphical data into instructions that manage the glowing effect of the display elements. A video presents examples of the simulated outcomes, demonstrating how I’m always captivated by the amusing and enjoyable aspects of science. Ramlan expressed to Decrypt their fascination with bioengineering as an amazing but insufficiently tapped resource for artistic and creative expression, a sentiment that guided them to join the Media Lab and the Department of Biological Engineering at MIT. This project exemplifies the kind of scientific endeavor I am passionate about—blending genetic manipulation with captivating and intellectually stimulating entertainment.